The ZIC1/2/3 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Zic family member 1 (ZIC1), and Zic-1. This antibody recognizes Human, and Mouse antigen. The ZIC1/2/3 Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' By similarity.Yokota N., Cancer Res. 56:377-383(1996)